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Literature summary extracted from

  • Bui, C.; Ouzzine, M.; Talhaoui, I.; Sharp, S.; Prydz, K.; Coughtrie, M.W.; Fournel-Gigleux, S.
    Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells (2010), FASEB J., 24, 436-450.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.23 5-aza-2'-deoxycytidine exposure of chondrosarcoma cells to the DNA-methyltransferase inhibitor 5-Aza-dc up-regulates expression of 3-OST1 mRNA Homo sapiens
2.8.2.29 5-aza-2'-deoxycytidine exposure of chondrosarcoma cells to the DNA-methyltransferase inhibitor 5-Aza-dc up-regulates expression of 3-OST2 mRNA Homo sapiens
2.8.2.30 5-aza-2'-deoxycytidine exposure of chondrosarcoma cells to the DNA-methyltransferase inhibitor 5-Aza-dc up-regulates expression of 3-OST3A mRNA Homo sapiens

Application

EC Number Application Comment Organism
2.8.2.23 medicine the results provide evidence for specific epigenetic regulation of 3-OST genes resulting in altered heparan sulfate proteoglycans and point to a defect of heparan sulfate-3-O-sulfation as a factor in cancer progression Homo sapiens
2.8.2.29 medicine the results provide evidence for specific epigenetic regulation of 3-OST genes resulting in altered heparan sulfate proteoglycans and point to a defect of heparan sulfate-3-O-sulfation as a factor in cancer progression Homo sapiens
2.8.2.30 medicine the results provide evidence for specific epigenetic regulation of 3-OST genes resulting in altered heparan sulfate proteoglycans and point to a defect of heparan sulfate-3-O-sulfation as a factor in cancer progression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.23 3-OST1 cDNA is inserted into the expression vector pCDNA3.1 for transfection of HEMC cells Homo sapiens
2.8.2.30 3-OST3A cDNA is inserted into the expression vector pCDNA3.1 for transfection of HEMC cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.23 Homo sapiens
-
-
-
2.8.2.29 Homo sapiens
-
-
-
2.8.2.30 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.23 chondrosarcoma cell H-EMC-SS chondrosarcoma cell Homo sapiens
-
2.8.2.29 chondrosarcoma cell H-EMC-SS chondrosarcoma cell Homo sapiens
-
2.8.2.30 chondrosarcoma cell H-EMC-SS chondrosarcoma cell Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.8.2.23 3-OST1
-
 Homo sapiens
2.8.2.23 heparan sulfate 3-O-sulfotransferase 1
-
 Homo sapiens
2.8.2.29 3-OST2
-
 Homo sapiens
2.8.2.29 heparan sulfate 3-O-sulfotransferase 2
-
 Homo sapiens
2.8.2.30 3-OST3
-
 Homo sapiens
2.8.2.30 heparan sulfate 3-O-sulfotransferase 3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.23 Homo sapiens exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST1 mRNA up
2.8.2.29 Homo sapiens exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST2 mRNA up
2.8.2.30 Homo sapiens exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST3A mRNA up